Regardless of its anatomic location, the hallmark genetic alteration of AdCC is a rearrangement of the MYB gene, most frequently in the form of MYB–NFIB fusion gene, resulting in the t(6;9)(q22–23;p23–24) translocation.77 The prevalence of such alteration ranges from 23 to 100% in breast AdCCs. Here, MYB is linked to adrenocortical carcinoma, hereditary.