EGFR and lung cancer: Overexpression of FASN in normal cells induces an oncogenic phenotype; the transformation involves enhanced lipid synthesis and an increase in phosphorylation and expression of EGFR.86 Using prostate and lung cancer cells Bollu et al.43 showed that EGFR activation involves FASN-dependent palmitoylation; this occurs intracellularly and is required for both EGFR ligand-dependent and ligand-independent activation.