This family consists of five enzymes that display phospholipase A1/2 and N- and O-acyltransferase activities.27 The tumor suppressor effects of RARRES3 have been attributed, by two investigative studies, to its activity as a phospholipase129 and, as mentioned earlier in this review, as an APT (due to its capacity to reduce palmitoylation levels of Wnt proteins).26 In the former study, phospholipase activity was associated with cellular changes in arachidonic acid. The gene discussed is PLAAT4; the disease is neoplasm.