The latter displays capacity for depalmitoylation; it was identified in gene signatures specific to bone and lung metastasis, and in breast cancer cells has been shown to modulate Wnt protein palmitoylation.26,36,37 ZDHHC2 is located at chromosome 8p21.3–22, which is frequently deleted or affected by loss of heterozygosity in metastatic cancers.18 An association between chromosome arm 8p and progression of breast cancer has been known for two decades,38,39 but the relevance of ZDHHC2 loss is only beginning to be understood. This evidence concerns the gene ZDHHC2 and metastatic malignant neoplasm.