EGF and cancer: The epidermal growth factor receptor family is composed of four protein-tyrosine kinases (EGFR/ERBB1 and ERBB2–4) that belong to the ErbB lineage of proteins.84 Overexpression of EGFR is associated with multiple cancers, tumor progression, and metastasis.43 Investigation into the cancer-promoting protein CDCP1 in ovarian cancer has revealed a role for palmitoylation in EGF-stimulated expression of CDCP1.85 Under basal conditions CDCP1 is constitutively internalized and degraded.