Because both previous literature and these univariate findings suggested that microenvironment subtype may predict survival among ER-positive (and/or hormone-treated) tumor patients, we conducted further Cox proportional hazards (multivariable) analyses adjusting for nodal status, intrinsic tumor subtype, tumor stage, tumor size, patient age in decade, and presence/absence of other cancer-adjacent genomic defects. The gene discussed is ESR1; the disease is neoplasm.