In the clinical setting, it was shown that the secondary metastatic site can induce the re-expression of E-cadherin in cancer cells, which is a critical step in the survival of cancer cells in the new microenvironment.47 The effect of re-expressing E-cadherin on integrin β1-subunits has, to the best of our knowledge, not been studied so far. This evidence concerns the gene CDH1 and cancer.