EIF2AK3 and dementia: While ISRIB was minimally effective at improving the learning and memory performance and neuropathological outcomes in these mouse strains, several other compounds targeting the PERK-eIF2α pathway have been found to ameliorate dementia-like or ER stress-related outcomes (Boyce et al., 2005; Kim et al., 2008; Lee et al., 2010a; Radford et al., 2015).