Recent evidence indicates that scheduled feeding during the active period helps to reinforce the function of the circadian clock system and can prevent disease progression or age-related changes including diet-induced obesity, cancer development, and cardiovascular dysfunction.56–59 Although the improvement of age-related cardiovascular dysfunction by scheduled feeding was demonstrated in a previous Drosophila study,57 the validation of this effect in higher-level organisms is required in a future study. Here, CLOCK is linked to obesity due to melanocortin 4 receptor deficiency.