For this purpose, we used induced pluripotent stem cells (iPSCs) generated from HGPS patients, which have previously been instrumental as a pharmacological platform for revealing drug effects in earlier studies carried out by our group.19–21 In the current study, we show that metformin applied to HGPS cells decreases progerin expression and reduces abnormalities in nuclear shape architecture and premature osteogenic differentiation, suggesting a therapeutic potential for a repurposing of this drug. The gene discussed is LMNA; the disease is Hutchinson-Gilford progeria syndrome.