ACE2 and Cognitive impairment: Moreover, the ACE2/Ang-(1–7)/Mas axis in the brain was also reported to have an important role in the regulation of blood pressure centrally and has an inhibitory neuromodulatory role in hypothalamic noradrenergic neurotransmission, and also acts as a cerebroprotective component by reducing neuronal apoptosis.8 Xie et al.9 recently reported that Ang-(1–7) significantly alleviated chronic cerebral hypoperfusion-induced cognitive deficits in rats.