Reduced adiposity, improved glucose homeostasis and reduced circulating lipids are characteristics of the pro-longevity intervention known as dietary restriction (DR), defined as reduced food intake without malnutrition, and linked an overall metabolic shift to FAO.22 Previously, DR-like phenotypes including improved insulin sensitivity and increased oxidative stress resistance have been observed in CS mouse models.23 We used indirect calorimetry to test the hypothesis that FAO was increased in CX mice despite ad libitum access to food. Here, INS is linked to malnutrition.