HTT and Alzheimer disease: Endocannabinoids can be produced in response to stress,44,45 and in rodent AD models cannabinoids reduce Aβ accumulation and improve memory.46,47 THC also reduces inducible huntingtin overexpression in PC12 cells,48 and both THC and endocannabinoids reduce inflammation.49,50 Several synthetic, plant derived and endogenous cannabinoids are able to prevent the accumulation of intraneuronal Aβ, reduce the production of eicosanoids, and block nerve cell death.