However, inflammatory adipokines such as TNF-α and MCP-1, during the course of adipocyte hypertrophy, were secreted in large amounts by adipocytes, and lead to impaired insulin signaling in the liver and skeletal muscle, thus inducing systemic insulin resistance.10,11 Although the presence of obesity is associated with decreases in the production/secretion of adiponectin, which has come to be characterized as a ‘beneficial’ adipokine.12 The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.