SIRT1 and Insulin resistance: In this regard, Accili and his colleagues further clarified that activation of SIRT139,40 leads to increases in blood levels of adiponectin as well as to improvements in hepatic insulin resistance in high-fat diet-fed mice,41 and that SIRT1 increases adiponectin or inhibits inflammatory cytokines by deacetylating PPARγ on Lys268 and Lys 293 (ref. 42).