Functional analyses in mice,5 hamsters,6 and rabbits7 have revealed that the protein encoded by the CETP gene mediates the transfer of cholesteryl esters from HDL-C to other lipoproteins such as atherogenic (V)LDL particle and is a key participant in the reverse transport of cholesterol from the periphery to the liver.8 Due to the function of CETP and the association of the gene with HDL-C in humans,9,10 the CETP gene is one of the targets for drug development for dyslipidemia.6,11,12CETP-inhibition leads to an increase of HDL-C from 30 up to 140% depending on the compound used. Here, CETP is linked to metabolic syndrome.