Patients with low renin/high aldosterone (primary aldosteronism phenotype) are best treated with aldosterone antagonists, those with low renin/low aldosterone (Liddle phenotype) are best treated with amiloride (a specific antagonist of ENac), and those with high renin/high aldosterone (secondary hyperaldosteronism, a renal phenotype) are best treated with angiotensin receptor blockers (ARBs). The gene discussed is REN; the disease is primary aldosteronism.