In adult tissues, the relevance of cadherin-mediated adhesion in cell sorting is best exemplified by its role in EMT and metastasis, where the loss of E-cadherin expression, along with the upregulation of N-cadherin, facilitates the displacement of N-cadherin invasive cells from the primary tumor, which is considered a hallmark of malignancy24,25. Here, CDH1 is linked to neoplasm.