The main pathways in the KEGG enrichment analysis were ‘Insulin resistance’ (P = 0.00628), ‘Phenylpropanoid biosynthesis’ (P = 0.043731), ‘Thyroid hormone synthesis’ (P = 0.008421), ‘Insulin signaling pathway’ (P = 0.003445) and ‘Starch and sucrose metabolism’ (P = 0.017741) (Fig. 3b). Here, INS is linked to Insulin resistance.