Obviously, other factors are involved in the regulation of the phosphorylation of these stress kinases, but it is tempting to speculate that in PA mouse heart the downregulation of p38 and JNK by miR-350 may be responsible, at least in part, for the development of myocardial hypertrophy via NFAT signaling pathways. The gene discussed is MAPK8; the disease is hypertrophy.