This extended gene network contained a number of transcription factors (Tbx5, Hand2, Fhl2, and Gata4) and ion/calcium handling genes (Ank2, Cacna2d2, Scn5a, Kcnd2, Kcnj5, Myoz2, Casq2, Csrp3, and Gja3) of interest in the context of atrial fibrillation. The gene discussed is SCN5A; the disease is atrial fibrillation.