Apparently, expression of heparanase correlates temporally and spatially in different cell types in the brain in different stroke models [16, 19, 32].Consistent with these findings, in our current study, a significant population of heparanase-positive cells in the SAH brain sections were not positive for NeuN staining, indicating SAH-associated heparanase expression in cells other than neurons (Fig. 2). Here, HPSE is linked to Stroke.