The study considered a cohort of 954 women with a personal and family history of breast cancer in which a high-risk BRCA1 or BRCA2 pathogenic variant had been excluded, and divided them divided into high, intermediate and low polygenic risk groups based on the quartiles of the distribution of the PRS, where the second and third quartiles formed the intermediate risk group. The gene discussed is BRCA1; the disease is breast cancer.