SHBG and breast carcinoma: Higher early pregnancy testosterone and SHBG were associated with higher breast cancer risk (testosterone, third vs first tertile OR(T3–T1): 1.46 (95% CI: 0.96–2.21), ptrend = 0.04; SHBG: 1.68 (1.05–2.70), ptrend = 0.13) (Table 2).