MAPT and Alzheimer disease: Derivatives of methylene blue have been shown to disrupt the aggregation of tau, such as RemberTM (a first-generation tau protein aggregation inhibitor), which showed some improvement in AD-related symptoms but failed in Phase II because of emergent side effects including diarrhea, urinary urgency, painful urination, dizziness, and falls [59, 60] (Clinical Trial Identifier: NCT00515333 and NCT00684944) (Table 1).