Glucose area under the curve (AUC, P = 0.002), insulin AUC (P < 0.001), the homeostatic model assessment of insulin resistance (HOMA-IR, P < 0.001), and the Matsuda index of insulin sensitivity (P < 0.001) all improved in a time-dependent manner following Phase 2 (Table 5). This evidence concerns the gene INS and Insulin resistance.