MALAT1 overexpression enhanced RNA pol (II), P300 and cell-cycle alteration and expression-elevated protein in tumour (CREPT) loading on the promoter region of telomere repeat-binding factor 2 (TRF2), triggering the overexpression, phosphorylation and small ubiquitin-like modifier (SUMO)ylation of TRF2 [19]. This evidence concerns the gene TERF2 and neoplasm.