It is clear that the regulatory activity of the ASH1L, CFLAR, CIRBP, EWSR1, HMGB3, LPP, NASP, NFIA, SMARCA4, SSRP1, TARDBP, WDR1, ZCCHC7 and ZNF160 TFs increased from the control to the AD-affected samples. The gene discussed is ASH1L; the disease is Alzheimer disease.