It is clear to find that SSRP1 and ZNF160 are continuously activated during the deterioration of AD; ASH1L, NFIA, ZBTB20, ZCCHC7 are upregulated in the incipient and moderate AD but downregulated in the severe AD; CFLAR and TARDBP are upregulated at the beginning of AD and downregulated during the deterioration; by contrast, EWSR1, NASP, CIRBP, MATR3 and ZNF131 are downregulated at the beginning of AD and upregulated when the disease gets worse; and the activities of HMGB3, LPP, SMARCA4 and WDR1 continuously decrease with the deterioration of AD. The gene discussed is ZBTB20; the disease is Alzheimer disease.