For example, TFs, such as ASH1L, CFLAR, HMGB3, ZNF160 and MATR3, displayed opposite behaviors on some cytokines; inflammatory factors; nuclear and tumor factors, such as IL-2, IL-6, NF-κB, and Irf3; immunogenic nucleic acids; papillomavirus E7/E6; caspase-3/caspase-8; Toll-like receptor; and so on. The gene discussed is MATR3; the disease is neoplasm.