These immune-related biological processes included the Wnt and MAPK signaling pathways, apoptosis, myeloid differentiation, neuroinflammation, B-cell differentiation, T cell-mediated immune responses, pathogen recognition and activation of innate immunity by cytokines, which are regulated by the same TFs, including CIRBP, LPP, SMARCA4, SSRP1 and WDR1, in both AD and BC, but in different directions. The gene discussed is CIRBP; the disease is breast cancer.