CIRBP, TARDBP, NASP, NFIA, HMGB3, ZCCHC7, SSRP1, WDR1, ZNF131 and MATR3 are upregulated in the grade Iof BC, but downregulated in either grade IIor grade III; among them, some TFs like NASP, NFIA, HMGB3 and ZCCHC7 are even upregulated again in grade III; by contrast, MATR3, ASH1L, EWSR1, LPP, ZBTB20, CFLAR are downregulated at the beginning of BC but upregulated in grade IIor grade III, sometimes they downregulated again when the disease getting into terminal period; SMARCA4 and ZNF160 continuously decrease with the deterioration of BC. The gene discussed is CIRBP; the disease is breast cancer.