From Table 4 we can see, for the first 17 TFs, their regulatory activities are in the same directions, such as ANK3, CYR61, ESR1, FOSB, HMGB3, IRX5, MYB, PRICKLE2, RETSAT, SPTBN1 and ZBTB16 are upregulated in both BC datasets, and DOK7, ECT2, FHL1, FOS, KRT19 and MESP1 are down-regulated in these two BC datasets. The gene discussed is HMGB3; the disease is breast cancer.