MYC and cancer: In conclusion, our results suggest that overexpression of MYC allows for sequence-specific binding to the NE motif AACGTT, and raise the intriguing possibility that the marked induction of de novo MYC binding to low-affinity AACGTT-containing genomic loci (especially those distal to promoters) could be important for the oncogenic effects of MYC overexpression that is characteristic of many cancers.