In addition, nephritis was more severe in PIL+/+ (40% proliferative GN (resembling human class III focal lupus nephritis), 60% mesangial GN (resembling human class II mesangial proliferative lupus nephritis)), while PIL-/- only had mild mesangial GN (Fig 4G–4I and Table 2). Here, SERPINA2 is linked to ganglioneuroma.