These findings implicated the MAPK pathway as a downstream target of avasimibe, which has been previously suggested.[15] To further investigate this, we performed mass cytometry screening of primary cells obtained from four BCR-ABL-independent resistant (RCML) and four imatinib-sensitive CML patients (SCML). This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.