NOTCH3 and neoplasm: Because Notch3 is only silenced in stromal cells, this phenotypic rescue can only point out an effect of DAPT treatment on the stroma and cannot be easily explained by a difference in the canonical pathway (that is, if DAPT is inhibiting tumour angiogenesis by blocking the canonical pathway induced by Notch receptors, knocking down Notch3 should only add more tumour angiogenesis inhibition).