OMP and bacterial infectious disease with sepsis: In a nonhuman primates model using 47-kDa OMP of Karp strain, a DNA plasmid vaccine (pKarp47) showed induction of sterile immunity against high-dose homologous intradermal challenge of O. tsutsugamushi; however, a virus-vectored vaccine (Kp47-VRP) itself was not effective for protection and elimination of bacteremia.31