LGG and BRCA had a significant overlap of 16 drivers (P = 1.39 × 10−14, hypergeometric test), including known cancer genes CDKN2A, HRAS, MYC and RB1. Both CDKN2A and RB1 were reported to have deletions in BRCA and LGG (Bieche and Lidereau, 2000; Debniak et al., 2004). Here, RB1 is linked to cancer.