FMR1 and schizophrenia: FMRP targets have been shown to be enriched in schizophrenia for exonic mutations (both de novo [Fromer et al., 2014] and segregating [Purcell et al., 2014]) while LoF intolerant genes have been shown to be enriched for rare exonic mutations in a large sequencing study of the disorder (Genovese et al., 2016).