Since this initial study, nucleolar localisation of RelA has been observed in response to the NSAIDs sulindac, sulindac sulphone and indomethacin [71], the naturally occurring derivative of estradiol and antitumor agent, 2-methoxyestradiol (2ME2) [104]; a potent Trk inhibitor and anti-tumour agent, K252a [105]; expression of the homeobox protein Hox-A5 (HOXA5) transcription factor [106], small molecule inhibitors of the CDK4 kinase [107] and the proteasome inhibitors MG132 and lactocystin [103]. Here, RELA is linked to neoplasm.