NFKB1 and cancer: The NSAIDs diclofenac, sulindac, sulindac sulphone sulindac sulphide, Tolfenamic, indomethacin, celocoxib and ibuprofen, which are all known to protect against colorectal cancer, have also been shown to induce degradation of IκB and nuclear translocation of NF-κB in various cancer cell lines in the absence of additional NF-κB stimuli [69,70,71,72,73,74,75].