EGFR and glioblastoma: While multiple authors have detailed the efficacy and safety of intracerebral delivery of EGFR variant III (EGFRvIII) targeting CAR-T cells and CAR-NK cells in a preclinical setting, there are only three clinical trials in which CAR-T cells have been delivered either intracranially or intrathecally for glioblastoma [12,14,15,19].