Based on the methods used to promote high levels of HA stalk-specific antibodies, similar approaches could be employed to induce strong humoral responses against NA, such as vaccination with a chimeric virus with genetically engineered HA and NA, sequential immunization with identical NA but less immunogenic HA, application of NA-based nanoparticles, or the direct supplementation of NA vaccine into the current seasonal influenza vaccines. This evidence concerns the gene XK and influenza.