Intriguingly, our double mutant screen has identified that unc-75/CELF displays synthetic interactions with both tdp-1/TDP-43 and fust-1/FUS, two genes that have been implicated in ALS (Sreedharan et al., 2008; Vance et al., 2009). This evidence concerns the gene CEBPD and amyotrophic lateral sclerosis.