CD4+ memory T cells and regulatory T (Treg) cells showed high enrichment for variants associated with a number of diseases, including RA, IBD and CeD.38 This observation converges with the previous immune studies pointing towards impaired function of Treg cells in autoimmune diseases.39 Notably, a study by the Todd group has demonstrated that Treg cells from patients with SLE have lower levels of CD25, the α‐chain of IL‐2 receptor, which affects their phenotype and decreases their survival.40 Here, CD4 is linked to autoimmune disease.