A comparison of PSA level, lipid profile, indices of central obesity, glucose level, and insulin level in treatment-naïve patients with CaP, patients treated with hormone manipulation alone, and patients treated with orchiectomy showed significant variations in mean values of PSA (P < .001), total cholesterol (P = .025), and BMI (P = .002). This evidence concerns the gene KLK3 and Abdominal obesity.