NR4A1 and breast carcinoma: Likely explanations for breast cancer as an increasing health threat include more prolonged longevity in many African communities (because breast cancer risk increases as women age); acceptance of Westernized, higher fat dietary patterns (which can increase breast cancer risk in both pre- and postmenopausal women); and increased adoption of reproductive patterns that are more prevalent in Western populations (such as delayed childbearing and reduced overall parity, which are risk factors that increase incidence of hormone receptor–positive breast cancer).