2004). Mice with ubiquitous loss of Bcl11a led to perinatal lethality and conditional knockout models showed reduction of cortical thickness and layer disorganization (John et al. 2012; Wiegreffe et al. 2015). Dias et al. (2016) described that Bcl11a haploinsufficiency leads to microcephaly in mice with heterozygous deletion of Bcl11a in accordance with the human phenotype. This evidence concerns the gene BCL11A and microcephaly.