Genomic germline analysis also revealed unexpected clinically relevant findings such us the presence of a Xeroderma pigmentosum C recessive pathogenic alteration, XPC (MIM: 613208) (p.L763Cfs*) in heterozygosis in a healthy patient with a family history of breast/ovary cancer and leukemia, or a mosaic pathogenic mutation in NF1 (MIM: 162200) (NF1 p.I679Dfs*21, allelic frequency 10.3%) in another healthy patient with a family history of gastrointestinal cancer, prostate cancer and leukemia. Here, NF1 is linked to leukemia.