INS and cancer: On the other hand, we identified four miRNAs (miR-125b-5p, miR-760, miR-30c and miR-136-5p) exclusively expressed in MCF-7 spheroids based on their potential roles in luminal-like breast tumorigenesis via regulation of a number of predicted cancer-associated pathways including JAK-STAT, calcium, and insulin signalling pathways.