To date, several SNPs have been identified in the CDKAL1 gene that exhibit an association with low insulin secretion in individuals with and without T2DM, depending upon the population (Wen et al., 2010; Hu et al., 2009; Tabara et al., 2009; Rong et al., 2009). This evidence concerns the gene CDKAL1 and type 2 diabetes mellitus.