TNF and myeloid sarcoma: The Th17 lymphocytes may be involved in the establishment of MS and EAE by recruitment of neutrophils into the CNS, induction of the reactive oxygen species (ROS) in CNS endothelial cells, activation of microglia cells to secrete pro-inflammatory mediators, and the induction of astrocytes to release CXC chemokines.3 Some Th17 lymhocyte-related cytokines (including TNF-α) elicit the expression of matrix metalloproteinases, which may play a considerable role in rupture of blood-brain barrier (BBB) during MS.38