UPB1 and hepatocellular carcinoma: Multivariate Cox’s proportional hazards regression analysis indicated that the expression of reticulon 3 (RTN3), suppressor of cytokine signaling 2 (SOCS2) and beta-ureidopropionase 1 (UPB1) were independent predictors for the prognosis of HCC patients (RTN3: hazard ratio [HR] = 1.469; 95% confidence interval [CI] = 0.454–0.717; P = 0.001; SOCS2: hazard ratio [HR] = 0.571; 95% confidence interval [CI] = 2.091–4.911; P < 0.0001; UPB1: hazard ratio [HR] = 0.648; 95% confidence interval [CI] = 0.519–0.810; P < 0.0001; Table 2).