Emerging data emphasise that TRAIL-R2 and TRAIL-R4, in addition to being apoptosis-regulating receptors, have the capacity to drive a pro-inflammatory/pro-proliferative state by activation of NFkB-dependent genes22, 27, 37, 38; the possibility that these receptors may therefore actively potentiate liver fibrosis (in addition to limiting its resolution) should therefore be investigated. Here, TNFRSF10D is linked to Hepatic fibrosis.