Interestingly, in the presence or absence of TGF-β, follistatin had no impact on proliferation in TGF-β superfamily signaling wild-type FET colon cancer cells (Fig. 2D), confirming that TGF-β induced activin pathway activation selectively affects colon cancer cell migration and not TGF-β- induced growth suppression. Here, FST is linked to malignant colon neoplasm.