In the disease association analysis (neoplasms, cancer or viral infections, breast neoplasms, neuroblastoma), the LMO3, MYB and BIRC3 oncogenes were also significantly upregulated whereas the WISP2, IGFBP5 and RASSF2 tumour suppressor genes were significantly downregulated in FFs compared to NFs. The gene discussed is IGFBP5; the disease is breast neoplasm.