In glioblastoma, a core set of transcription factors including SOX2, oligodendrocyte transcription factor 2 (OLIG2), POU class 3 homeobox 2 (POU3F2), and spalt-like transcription factor 2 (SALL2) have been shown to be required for reprogramming differentiated glioblastoma cells into stem-like states25. The gene discussed is SOX2; the disease is glioblastoma.