Additionally, we found that the AUC of HOXA11-AS was 0.878 (95% CI: 0.786–0.969) for lung adenocarcinoma and 0.962 (95% CI: 0.928–0.996) for lung squamous cell carcinoma, which predicted a diagnostic value of HOXA11-AS in NSCLC. This evidence concerns the gene HOXA11 and lung adenocarcinoma.