We hypothesize that HOXA11-AS could affect proliferation, invasion, migration, apoptosis and cell cycle of NSCLC, in part because HOXA11-AS affected the non-small cell lung cancer pathway, such as the ErbB signaling pathway, PI3K-Akt signaling pathway and MAPK signaling pathway. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.