In A549 cells, the size of the tumor xenografts was significantly reduced after transfection with HOXA11-AS RNAi-54 (127.1 ± 232.728 mm3 vs 528.667 ± 382.206 mm3, t = −2.008, P = 0.045) compared with the lenti-control virus group. This evidence concerns the gene HOXA11 and neoplasm.