We also evaluated the implication of genetic variants associated with LS and non-LS, as reported in our recent work17 in T-cells (CD4+ and CD8+) and CD4/CD8 in blood of the healthy and lung of the diseased (through broncoalveolar lavage fluid - BAL), as a measure of pleiotropy23, 24. The gene discussed is CD8A; the disease is Leigh syndrome.