Enrichment analysis based on overlapping variants (defined by intersected sets) between sarcoidosis phenotypes (LS and non-LS) and T-cell subtypes in both blood and in lung revealed exciting findings, which highlighted immune responses related to antigen presentation by MHC molecules class I and II, signaling pathways, such as complement pathway and TRL signaling pathway, and T-cell regulatory mechanisms – all which are relevant to pathogenesis of sarcoidosis, a disease alleged to be T-cell driven. The gene discussed is HLA-C; the disease is sarcoidosis.