CD4 and Leigh syndrome: In particular, the evaluation of 1,900 LS-associated variants with meta-P < 5 × 10−5 as has been previously published17 revealed that several LS-associated variants were also associated with CD4+ and CD8+ T-cell relative counts and CD4/CD8 ratio in the blood of the healthy and in the BAL of LS cases, at a significance threshold of P < 0.05.