CD4 and Leigh syndrome: Using pruned genic-SNPs, the genetic contributions were: from 4.1% to 11.6% by variants associated with LS; from 4.3% to 7.0% by variants associated with CD4+ and CD8+ T-cell relative counts and CD4/CD8 ratio; and from 0.2% and 1.5% by variants associated with both LS and T-cell relative counts.